AN EZ-BREED canine DNA Test will reveal your dog's genetic background back to the great-grandparent level, provide a predicted weight profile and test for the MDR1 genetic mutation. The covers more than 250 breeds and varieties including almost all those recognized by the American Kennel Club (AKC) and can be run for mixed-breed, designer, or purebred dogs. The procedure is the same for all three, but you decide at the time of activation how you would like to run it. For purebred and designer dogs, the test will provide a Principle Component Analysis chart comparing your dog with others of that same breed(s) in our database and for purebred tests specifically, an additional Homozygosity Profile.
For many years now Wisdom sectionŽ has provided genetic mutation tests through their veterinary products and now, for the first time, they are including one of these important tests in their at-home swab product. Included in the Wisdom section 3.0 tests is the MDR1 Gene Mutation Test licensed from Washington State University, for use by Mars Veterinary.
MDR1 or Multi-Drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed breed dogs. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs.
Some dogs, particularly herding breeds or mixed-breed dogs with herding breed ancestry have a mutation in the MDR1 gene that makes them defective in their ability to limit the absorption and distribution of many drugs. These dogs are also slower to eliminate drugs from the body that are transported by P-glycoprotein. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.
Is your dog from a country outside the contiguous US, UK, Canada, Australia or Germany?
The Wisdom sectionŽ Canine DNA Test was developed using pure breeds primarily from those found on The Kennel Club and the American Kennel Club registry lists. If your dog was imported from a country other than Canada, the UK, Australia, Germany, or mainland U.S., or you suspect that your dog's ancestors are from outside these countries; his breed ancestry may not be well represented in the Wisdom section breed database.